Direct Meds
Direct Meds sells compounded GLP-1s, sermorelin, NAD+ and glutathione, most as a 90-day supply billed monthly. It prints more strengths than most sellers. Its claims are loud, and none is sourced.
Review by Molly Ward, goal-guide writer · Updated September 2026
The short version
Direct Meds is a reasonable choice if you want sermorelin or NAD+ with the strength on the page and no membership fee. The catch is the paperwork. The product pages say cancel anytime, the terms describe a subscription with no refund on medication received, and the claims copy cites nothing.
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Lowest listed: NAD+ nasal spray, from $119/mo
Every state but Alabama and Mississippi
Visit Direct Meds →Direct Meds is a cash-pay online prescriber for weight loss, longevity and wellness. Its catalog runs from compounded semaglutide and tirzepatide to sermorelin, NAD+ and glutathione, alongside supplements, hair medicines and skin creams.
What Direct Meds prescribes, by goal
Weight
- SemaglutideFDA-approved
- Injection (compounded)From $297/mo
- Sublingual (compounded)From $249/mo
- TirzepatideFDA-approved
- Injection (compounded)From $399/mo
- Sublingual (compounded)From $299/mo
Semaglutide and tirzepatide come as weekly injections or as sublingual drops. Each is priced on a 90-day supply billed monthly. The sublingual semaglutide page prints its daily dose; the injection pages print none.
Longevity
- NAD+Legal to compound
- Nasal spray (compounded)From $119/mo
- Injection (compounded)From $199/mo
- GlutathioneLegal to compound
- Injection (compounded)From $249/mo
NAD+ comes as a daily weekday injection in 500 mg or 1,000 mg strengths, or as a nasal spray at 15 mg per spray. Glutathione is a 200 mg per mL injection into the muscle. Both are cheaper per month on the 90-day supply.
Recovery
- SermorelinLegal to compound
- Injection (compounded)From $249/mo
Sermorelin is the recovery product here. The page tells you to reassess with your doctor every three to six months, with labs, but does not say who orders them.
Sleep
- SermorelinLegal to compound
- Injection (compounded)From $249/mo
Sermorelin is injected at bedtime, five nights a week. The page prints the dose: 300 mcg a night for the first four weeks, then 600 mcg. It is $249 a month on a 90-day supply, or $299 for a single month plus shipping.
Each “From” figure is the seller’s own starting price, in the unit the seller states. Where a required fee or a package length changes what one month costs, the smaller line under it is our arithmetic, not a figure the seller prints. Compounded preparations are not FDA-approved.
Who prescribes
A licensed clinician
The site says a U.S.-licensed physician or licensed provider reviews every intake, usually within a day. Prescribers are not named on the product pages. The team page names a physician as chief medical officer, and a nursing team answers questions on demand.
There is no appointment. You take an online quiz and fill in an intake form, and a provider reviews it, often within a few business hours. After that, a care team and on-demand nurses handle questions by message.
Are labs required?
Not required to start
No product page requires labs before you start, and no lab price is published. The sermorelin page suggests a review with your doctor every three to six months, based partly on labs.
Ready to start with Direct Meds?
Lowest listed price: NAD+ nasal spray, from $119/mo. Confirm it on the seller’s own site.
What it claims, and what it cites
The copy is confident and unsourced. Sermorelin is called clinically proven, with visceral fat said to fall by months three to six. NAD+ is sold as a biohack for focus and memory. The GLP-1 pages speak of meaningful, sustained weight loss. No page links a study. The GLP-1 copy has drawn a federal warning. FDA letter 716822, dated September 9, 2025, was addressed to the company under its trading name, DirectMeds. It quoted the line that compounded semaglutide contains the same active ingredient as branded semaglutide, and a matching line for tirzepatide. The FDA said those claims implied the compounded drugs were FDA-approved, and they are not.
| On Direct Meds’s site | Source it gives |
|---|---|
| On Direct Meds’s site“Clinically Proven Peptide Therapy” | Source it givesNone given |
| On Direct Meds’s site“Months 3–6: Visceral fat trends down, lean mass trends up” | Source it givesNone given |
| On Direct Meds’s site“Enhance cognitive function, focus, and memory” | Source it givesNone given |
| On Direct Meds’s site“High bioavailability (89%)” | Source it givesNone given |
Sold by Direct Meds, not listed here
- BPC-157
- On no 503A list (removed from Category 2 in April 2026, never in Category 1). The FDA's compounding advisory committee voted 8–6 (one abstention) in July 2026 to favor listing it; the vote is a recommendation, not binding on the FDA, and pharmacies may not compound it until final rulemaking.
- Tesamorelin
- Approved only as Egrifta, for excess abdominal fat in adults with HIV-associated lipodystrophy. Its label says it is not indicated for weight loss. Egrifta became a biologic (BLA) on March 23, 2020, and FDA says compounded versions of these products do not qualify for the 503A or 503B compounding exemptions.
- Supplements, hair and skin products
- Appetite supplements, finasteride, minoxidil and face and pain creams. None is a peptide.
- Estrogen, progesterone and DHEA
- Hormone treatments, which this site does not cover.
How it bills
Most products are priced per month on a 90-day supply that ships at once, and a 30-day supply costs more. The product pages promise no membership fee and cancel anytime, and shipping is free. The terms describe a subscription that renews every 30 days until you turn off auto-refill at least 48 hours before the next charge. Medication you have received is not refunded, and a return carries a $35 disposal fee.
Availability: Every state but Alabama and Mississippi
LegitScript: seal displayed on the seller’s site
For and against
- For: Prints sermorelin and NAD+ strengths
- For: NAD+ as injection or nasal spray
- For: No membership fee
- For: No appointment needed
- Against: Terms describe an auto-renewing plan
- Against: No refund on medication received
- Against: Claims cite no study
- Against: Best prices need a 90-day supply
- Against: FDA warning letter 716822 in 2025
The evidence behind what it sells
- Tirzepatide Headache: What the Labels and Trial Results Recorded
- Does NAD Cause Cancer? What Human and Animal Studies Show
- Sermorelin vs HGH: A Signal to the Pituitary or the Hormone Itself
- Does Tirzepatide Make You Tired? What the Trials and Labels Show
- NAC vs Glutathione: Which One Raises Glutathione in People?
- Does Sermorelin Work? What the Human Studies Measured
Right for
Readers who want sermorelin or NAD+ with the strength printed, and who are happy to take three months of supply in one box.
Look elsewhere if
Anyone who wants sourced claims, a month-to-month price as the headline, or a clear refund if they stop early.
Other sellers for weight
50 Stars Health
Also prescribes Semaglutide, Tirzepatide.
Actin
Also prescribes Semaglutide, Tirzepatide.
AgelessRx
Also prescribes Semaglutide, Tirzepatide.
Direct Meds
Frequently asked questions
- Does Direct Meds require blood work for sermorelin?
- Not to start. The sermorelin page suggests reviewing your progress with your doctor every three to six months, partly on labs.
- Is a Direct Meds order a subscription?
- The terms say yes for certain products. They renew every 30 days until you turn off auto-refill at least 48 hours before the next charge.
- Does Direct Meds sell NAD+ as a nasal spray?
- Yes. It sells NAD+ as an injection or as a nasal spray, and the spray is cheaper per month on the 90-day supply.
- Has Direct Meds received an FDA warning letter?
- Yes. Letter 716822, dated September 9, 2025, objected to the site saying its compounded semaglutide and tirzepatide share an active ingredient with the brand-name drugs. The FDA's position is that compounded drugs are not FDA-approved.
See what Direct Meds prescribes today
Direct Meds sets its own prices, plans and the states it serves. Check them before you start.