The peptides you can be prescribed.
10 peptides are FDA-approved or legal to compound in the U.S. today, and each has a guide here. Tesamorelin counts only as a brand-name drug, approved for a use no goal here covers. Compounded versions are not permitted, so we link no seller for it. Each guide names its FDA source, the studies behind it, and what those studies did not measure.
- SemaglutideFDA-approved · WeightA once-weekly GLP-1 injection with some of the largest trials of any drug on this site. The trials studied the approved product; most telehealth sellers dispense a compounded version.Weight: Large trials
- TirzepatideFDA-approved · WeightA once-weekly injection that acts on two gut-hormone receptors. Its obesity trial is among the largest on this site, and a withdrawal trial measured what happens when it stops.Weight: Large trials
- LiraglutideFDA-approved · WeightA once-daily GLP-1 injection, approved for weight management as Saxenda in 2014. Two 56-week trials measured how much weight it took off, and how much of a diet's loss it helped keep off.Weight: Large trials
- OrforglipronFDA-approved · WeightA once-daily GLP-1 tablet, and a small molecule rather than a peptide. Its 72-week phase 3 trial in 3,127 adults measured weight loss against placebo, not against the injected drugs.Weight: Large trials
- TesamorelinApproved as a brand only · WeightA daily injection approved for one use: excess belly fat in adults with HIV-associated lipodystrophy. Its trials measured fat around the organs, and its label says it is not a weight-loss drug.No cited study measured a goal outcome
- PT-141 (bremelanotide)FDA-approved · Sexual healthThe one peptide on this site approved for sexual desire. Two phase 3 trials support it for premenopausal women with low desire; the benefit they measured was modest and nausea was common.Sexual health: Large trials
- SermorelinLegal to compound · Sleep, RecoveryA short copy of the hormone that tells the pituitary to release growth hormone. Small 1990s studies show it raises growth hormone; none tested it against placebo for aging, body composition or sleep.Sleep: Small studies · Recovery: Early human data
- NAD+Legal to compound · LongevityA coenzyme every cell uses to make energy, now sold as injections and nasal sprays. It may be compounded; the human evidence for giving it directly is two small infusion studies.Longevity: Early human data
- GlutathioneLegal to compound · LongevityThe body's own antioxidant, sold as injections, sprays and tablets. Taken by mouth it raises the body's stores while you take it; in the trials that tested a disease outcome it did not beat placebo.Longevity: Small studies
- GHK-CuLegal to compound · RecoveryA copper-carrying peptide sold for skin and healing. It may be compounded only in non-injectable forms, and the human trials are about wounds, with mixed results.Recovery: Small studies